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Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

Sodium ascorbate [134-03-2]

Imprimer

Référence B1834-1ml

Conditionnement : 10mM(in1mLH2O)

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Background

Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.

Chemical Properties

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	198.11
Cas No.	134-03-2
Formula	C₆H₇NaO₆
Solubility	≥44.2 mg/mL in DMSO; ≥2.82 mg/mL in EtOH with ultrasonic; insoluble in H2O
Chemical Name	sodium (R)-2-((S)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate
SDF	Download SDF
Canonical SMILES	O=C1C(O)=C([O-])[C@@H]([C@@H](O)CO)O1.[Na+]
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]
Cell lines	Human glioblastoma multiforme (GBM), rat prostate cancer (PC) and normal mouse 3T3 cells
Reaction Conditions	1 ~ 14 mM sodium ascorbate
Applications	Sodium ascorbate considerably decreased the proliferation and motility of GBM and PC cells. This effect was accompanied by intracellular ROS over-production and necrotic death of tumor cells, apparently resulting from their "autoschizis".
Animal experiment:[1]
Animal models	Male Wistar rats, 200 ~ 230 g
Dosage form	1 or 2 mg/kg Injected intravenously at 3rd and 7th day after U87 cell implantation
Applications	In U87 tumor-bearing rats, intravenous administration of sodium ascorbate inhibited tumor invasion in vivo and seemed to reduce the size of neoplasia. Concomitantly, blood analyses did not show any signs of hemolysis or biochemical disorders after sodium ascorbate administration. High doses of sodium ascorbate were demonstrated to interfere with the expansion of GBM cells in vitro and in vivo.
Note	The technical data provided above is for reference only.
	References: 1. Ryszawy D, Pudełek M, Catapano J, et al. High doses of sodium ascorbate interfere with the expansion of glioblastoma multiforme cells in vitro and in vivo. Life Sciences, 2019, 232: 116657.

Quality Control

Purity = 99.94%

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