STM2457 [2499663-01-1]
Référence HY-134836-25mg
Conditionnement : 25mg
Marque : MedChemExpress
STM2457 is a first-in-class, highly potent, selective and orally active METTL3 inhibitor with an IC50 of 16.9 nM. STM2457 can be used for the research of acute myeloid leukaemia (AML).
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STM2457 Chemical Structure
CAS No. : 2499663-01-1
This product is a controlled substance and not for sale in your territory.
Based on 26 publication(s) in Google Scholar
Description |
STM2457 is a first-in-class, highly potent, selective and orally active METTL3 inhibitor with an IC50 of 16.9 nM. STM2457 can be used for the research of acute myeloid leukaemia (AML)[1][2]. |
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In Vitro |
STM2457 (Compound 72) inhibits MOLM13 cells proliferation with an IC50 of 8.699 μM[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Masse moléculaire |
444.53 |
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Formule |
C25H28N6O2 |
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CAS No. |
2499663-01-1 |
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Appearance |
Solid |
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Color |
White to yellow |
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SMILES |
O=C(C(N=C1N2C=CC=C1)=CC2=O)NCC3=CN4C=C(CNCC5CCCCC5)C=CC4=N3 |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
DMSO : 50 mg/mL (112.48 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.2496 mL | 11.2478 mL | 22.4957 mL | 56.2392 mL |
5 mM | 0.4499 mL | 2.2496 mL | 4.4991 mL | 11.2478 mL | |
10 mM | 0.2250 mL | 1.1248 mL | 2.2496 mL | 5.6239 mL | |
15 mM | 0.1500 mL | 0.7499 mL | 1.4997 mL | 3.7493 mL | |
20 mM | 0.1125 mL | 0.5624 mL | 1.1248 mL | 2.8120 mL | |
25 mM | 0.0900 mL | 0.4499 mL | 0.8998 mL | 2.2496 mL | |
30 mM | 0.0750 mL | 0.3749 mL | 0.7499 mL | 1.8746 mL | |
40 mM | 0.0562 mL | 0.2812 mL | 0.5624 mL | 1.4060 mL | |
50 mM | 0.0450 mL | 0.2250 mL | 0.4499 mL | 1.1248 mL | |
60 mM | 0.0375 mL | 0.1875 mL | 0.3749 mL | 0.9373 mL | |
80 mM | 0.0281 mL | 0.1406 mL | 0.2812 mL | 0.7030 mL | |
100 mM | 0.0225 mL | 0.1125 mL | 0.2250 mL | 0.5624 mL |