B7750-50mg | TC-E 5003 [17328-16-4] Clinisciences

Background

TC-E 5003 is a selective inhibitor of PRMT1 with IC50 value of 1.5 μM [1].
PRMT1 is a member of the protein arginine N-methyltransferase (PRMT) family and plays a pivotal role in many biological processes by post-translational modification of target proteins. It has been reported that PRMT1 abnormal expression was observed in many types of cancer and its inhibitors was regarded as promising target in clinic [2].
TC-E 5003 is a potent PRMT1 inhibitor. When tested with breast cancer cell line MCF7a or prostate cancer cell line LNCaP, TC-E treatment induced cell apoptosis and inhibited cell proliferation by functioning on PRMT1. And it also reported that TC-E treatment attenuated androgen-induced gene expression in LNCaP cells [1].
References:
[1]. Bissinger, E.M., et al., Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem, 2011. 19(12): p. 3717-31.
[2]. Avasarala, S., et al., PRMT1 is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-Small Cell Lung Cancer. J Biol Chem, 2015.

Product Citation

1. Qi Zhu, Dinghui Wang, et al. "Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C/EBPβ and PPARγ." J Biol Chem. 2022 Jul 31;102309. PMID: 35921899

Chemical Properties

Physical Appearance	Off-white solid
Storage	Store at -20°C
M.Wt	401.26
Cas No.	17328-16-4
Formula	C₁₆H₁₄Cl₂N₂O₄S
Solubility	insoluble in EtOH; insoluble in H2O; ≥49 mg/mL in DMSO
Chemical Name	N,N'-(sulfonylbis(4,1-phenylene))bis(2-chloroacetamide)
SDF	Download SDF
Canonical SMILES	ClCC(NC1=CC=C(C=C1)S(=O)(C(C=C2)=CC=C2NC(CCl)=O)=O)=O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Purity = 98.10%

Chemical structure

TC-E 5003 [17328-16-4]

Référence B7750-50mg

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