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Veratridine [71-62-5]
Référence 10-1017-10mg
Conditionnement : 10mg
Marque : Focus Biomolecules
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Veratridine | Na channel activator
CAS:
71-62-5
Catalog Number:
10-1017
Activity:
Na channel activator
Molecular Weight:
673.81
Molecular Formula:
C36H51NO11
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Veratridine (71-62-5) is a steroidal alkaloid voltage-gated Na+ channel activator.1 Veratridine may be used to increase Na+ concentration in cardiomyocytes2 and in cultured sympathetic neurons3. Toxic: LD50=1.35 mg/Kg (mouse i.p.)
References/Citations:
1) Fekete et al. (2009), Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy; J. Neurochem., 111 745
2) Chen et al. (1997), Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes; Eur. J. Pharmacol., 333 261
3) Koike et al. (2000), Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro; Brain Res. Bull., 51 345
CAS:
71-62-5
Catalog Number:
10-1017
Activity:
Na channel activator
Molecular Weight:
673.81
Molecular Formula:
C36H51NO11
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee
Veratridine (71-62-5) is a steroidal alkaloid voltage-gated Na+ channel activator.1 Veratridine may be used to increase Na+ concentration in cardiomyocytes2 and in cultured sympathetic neurons3. Toxic: LD50=1.35 mg/Kg (mouse i.p.)
References/Citations:
1) Fekete et al. (2009), Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy; J. Neurochem., 111 745
2) Chen et al. (1997), Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes; Eur. J. Pharmacol., 333 261
3) Koike et al. (2000), Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro; Brain Res. Bull., 51 345
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