General Info
| Host: | Mouse |
| Applications: | FC/IP |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-CD19 is suitable for use in Flow Cytometry and Immunoprecipitation research applications. |
| Clonality: | Monoclonal |
| Clone ID: | LT19 |
| Conjugation: | Biotin |
| Isotype: | IgG1 |
| Formulation: | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Concentration: | 1 mg/mL |
| Storage Instruction: | Store at 2-8°C upon receipt. |
Information
| Gene Symbol: | CD19 |
| Gene ID: | 930 |
| Uniprot ID: | CD19_HUMAN |
| Immunogen: | Daudi human Burkitt lymphoma cell line |
Description
| Tissue Specificity | Detected on marginal zone and germinal center B cells in lymph nodes. Detected on blood B cells (at protein level). |
| Post Translational Modifications | Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-531 is extremely rapid, followed by phosphorylation at Tyr-409. In contrast, phosphorylation of Tyr-500 appears more slowly and is more transient, returning rapidly to basal levels. |
| Function | Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge. |
| Protein Name | B-Lymphocyte Antigen Cd19B-Lymphocyte Surface Antigen B4Differentiation Antigen Cd19T-Cell Surface Antigen Leu-12Cd Antigen Cd19 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-198933Reactome: R-HSA-2219530Reactome: R-HSA-6811558Reactome: R-HSA-977606Reactome: R-HSA-983695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Antibody Names | Anti-B-Lymphocyte Antigen Cd19 antibodyAnti-B-Lymphocyte Surface Antigen B4 antibodyAnti-Differentiation Antigen Cd19 antibodyAnti-T-Cell Surface Antigen Leu-12 antibodyAnti-Cd Antigen Cd19 antibodyAnti-CD19 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance