Anti-CD52 (CAMPATH-1) (Mouse) mAb-FITC
Referência D204-4
Tamanho : 100ul
Marca : MBL International
Please Note: MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: https://www.cosmobiousa.com/. For Non-US inquiries reach out to MBL in Japan: https://www.mblbio.com/.
D204-4
Antibody
100 µl
Monoclonal antibody conjugated to FITC of 100 µl targeting CAMPATH-1/CD52 for FCM.
Target | CAMPATH-1/CD52 |
---|---|
Product Type | Antibody |
Application | FCM |
Clonality | Monoclonal |
Conjugate | FITC |
Isotype | IgG2a |
Immunogen | Transgenic mouse spleen cell IL-2Ralpha |
Host Species | Rat |
Species Reactivity | Mouse |
Formulation | 50 μg IgG in 100 μl volume of PBS containing 1% BSA and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into drain. |
Research Area | Immunology, Cell Biology |
Description/Background | CAMPATH-1, also known as CD52, is a heavily glycosylated, GPI-anchored protein expressed at high levels on almost all thymocytes, lymphocytes, monocytes, and macrophages. The function of CD52 is unknown. However, CD52 is an exceptionally good target for complement-mediated cell lysis and antibody-mediated cellular cytotoxicity. Humanized CAMPATH-1antibodies have been used therapeutically to effectively deplete lymphocytes in allogeneic bone marrow transplants, hematologic malignancies, and autoimmune diseases. Clinical trials suggest CAMPATH-1 antibodies are especially promising in the treatment of leukemia, non-Hodgkin lymphomas, and rheumatoid arthritis. The apparent size of CAMPATH-1 by SDS-PAGE is 25-29 kDa; however, the actual molecule is much smaller, ~ 8-9 kDa as confirmed by total structure analysis and mass spectrometry. |
Storage Temperature | 4°C |
Protocols | FCM |
Clone Number | BTG-2G |
Concentration | 500 μg/ml |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
D204-4
Antibody
100 µl