Anti-Chromogranin A antibody (1-100) (Clone: S6MR)

Clonality:	Monoclonal
Clone ID:	S6MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CHGA
Gene ID:	1113
Uniprot ID:	CMGA_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Chromogranin A (P10645).
Immunogen Sequence:	MRSAAVLALLLCAGQVTALP VNSPMNKGDTEVMKCIVEVI SDTLSKPSPMPVSQECFETL RGDERILSILRHQNLLKELQ DLALQGAKERAHQQKKHSGF

Tissue Specificity	Detected in cerebrospinal fluid (at protein level). GE-25: Found in the brain.
Post Translational Modifications	Sulfated on tyrosine residues and/or contains sulfated glycans. O-glycosylated with core 1 or possibly core 8 glycans. Contains chondroitin sulfate (CS).CS attachment is pH-dependent, being observed at mildly acidic conditions of pH 5 but not at neutral pH, and promotes self-assembly in vitro. Proteolytic processing gives rise to an additional longer form of catestatin (residues 358-390) which displays a less potent catecholamine release-inhibitory activity. Plasmin-mediated proteolytic processing can give rise to additional shorter and longer forms of catestatin peptides.
Function	Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas. Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Acts as a potent scavenger of free radicals in vitro. May play a role in the regulation of cardiac function and blood pressure. Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Protein Name	Chromogranin-A Cga Pituitary Secretory Protein I Sp-I Cleaved Into - Vasostatin-1 Vasostatin I - Vasostatin-2 Vasostatin Ii - Ea-92 - Es-43 - Pancreastatin - Ss-18 - Wa-8 - We-14 - Lf-19 - Catestatin Sl21 - Al-11 - Gv-19 - Gr-44 - Er-37 - Ge-25 - Serpinin-Rrg - Serpinin - P-Glu Serpinin Precursor
Database Links	Reactome: R-HSA-6803157
Cellular Localisation	Serpinin: Secreted Cytoplasmic Vesicle Secretory Vesicle Pyroglutaminated Serpinin Localizes To Secretory Vesicle Neuronal Dense Core Vesicle Secreted Associated With The Secretory Granule Membrane Through Direct Interaction To Scg3 That In Turn Binds To Cholesterol-Enriched Lipid Rafts In Intragranular Conditions In Pituitary Gonadotropes Located In Large Secretory Granules
Alternative Antibody Names	Anti-Chromogranin-A antibody Anti-Cga antibody Anti-Pituitary Secretory Protein I antibody Anti-Sp-I Cleaved Into - Vasostatin-1 antibody Anti-Vasostatin I - Vasostatin-2 antibody Anti-Vasostatin Ii - Ea-92 - Es-43 - Pancreastatin - Ss-18 - Wa-8 - We-14 - Lf-19 - Catestatin antibody Anti-Sl21 - Al-11 - Gv-19 - Gr-44 - Er-37 - Ge-25 - Serpinin-Rrg - Serpinin - P-Glu Serpinin Precursor antibody Anti-CHGA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance