Anti-P53 Antibody (Phospho-Ser37)
Referência OAAI00469
Tamanho : 100ug
Marca : Aviva Systems Biology
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Telefone : +1 850 650 7790
Anti-P53 Antibody (Phospho-Ser37) (OAAI00469)
| Datasheets/Manuals | Printable datasheet for Anti-P53 Antibody (Phospho-Ser37) (OAAI00469) |
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| Predicted Species Reactivity | Human|Mouse|Rat |
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| Product Format | Liquid. This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Application | ELISA, FC, IHC, IP, WB |
| Additional Information | Background: P53, also known as protein 53, or tumor suppressor protein 53, plays important roles in cellular response to DNA damage and other genomic aberration. Mutations in the p53 tumor suppressor gene giving rise to mutant p53 proteins are among the most common genetic alterations associated with tumor cells. P53 protein is phosphrylated at multiple sites in vivo and in vitro in response to different stimuli. UV caused DNA damage can induce Ser9, Ser15, Ser20 phosphorylation while ATM, ATR, DNA-PK at Ser15 and Ser37. |
| :: | Positive Control: UV treated Hela cells, Breast carcinoma |
| :: | Cellular Location: Nuclear |
| Reconstitution and Storage | The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles. |
| Immunogen | A synthetic peptide corresponding to the epitope -LPSPH- at a phosphorylation site at serine 37 of human p53 protein |
| Purification | Affinity Purified |
| Concentration | 100ug/200ul |
| Target Post-Translational Modification | Phosphorylated |
| Specificity | TP53 |
| Formulation | This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer |
| Application Info | WB: 0.1-1 ug/ml | ELISA: 0.01-0.1 ug/ml | IP: 2-5 ug/ml | IHC: 2-10 ug/ml | FC: Not tested |
| Reference | Sylvie Labrecque, et al. Analysis of the Anti-p53 Antibody Response in Cancer Patients (1993) Cancer Research 53, 3468-3471 |
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| Gene Symbol | TP53 |
| Gene Full Name | tumor protein p53 |
| Alias Symbols | antigen NY-CO-13;BCC7;BMFS5;cellular tumor antigen p53;LFS1;mutant tumor protein 53;P53;p53 tumor suppressor;phosphoprotein p53;transformation-related protein 53;TRP53;tumor protein 53;tumor supressor p53. |
| NCBI Gene Id | 7157 |
| Description of Target | P53, also known as protein 53, or tumor suppressor protein 53, plays important roles in cellular response to DNA damage and other genomic aberRation. Mutations in the p53 tumor suppressor gene giving rise to mutant p53 proteins are among the most common genetic alteRations associated with tumor cells. P53 protein is phosphrylated at multiple sites in vivo and in vitro in response to different stimuli. UV caused DNA damage can induce Ser9, Ser15, Ser20 phosphorylation while ATM, ATR, DNA-PK at Ser15 and Ser37. |
| Uniprot ID | P04637 |
| Molecular Weight | 53 |
