Kir2.1 (KCNJ2) is a member of the inward rectifier potassium ion channel family which also includes Kir2.2 and Kir2.3. Kir2.1 is expressed in the membranes of many tissues, including heart, skeletal muscle, kidney and diffusely distributed throughout the brain. Kir2.1 has a role in cardiac excitability and has been shown to have interactions with CLG4, Interleukin 16 and TRAK2. Defects in Kir2.1 are involved with the diseases long QT syndrome type 7 (also known as andersen-Tawil syndrome), short QT syndrome 3, and Familial Atrial Fibrillation 9.
Purified by Protein A chromatography
0.5 mg/mL
Monoclonal
N112B/14
IgG1
ICC, IHC
Mouse
Kcnj2 Irk1
55 kDa
Synthetic peptide amino acids 390-411 (cytoplasmic C-terminus) of mouse Kir2.1 (accession number P35561)
Human, Mouse, Rat
AB_2939777
Aliquot and store at -8% specific antibody.
PBS with 0.09% azide
FL550 Ex: 550 nm, Em: 575 nm
No cross-reactivity against Kir2.2 or Kir2.3
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.