Biological Activity

Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.

Chemical Information

Molecular Weight	494.52
Formula	C20H22N4O5.CH4O3S
CAS Number	59721-29-8
Solubility (25°C)	DMSO 60 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Serap Şimşek-Yavuz, et al. An update of anti-viral treatment of COVID-19

[2] Peter Breining, et al. Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety

[3] Dwight L McKee, et al. Candidate drugs against SARS-CoV-2 and COVID-19

[4] Yoshiharu Uno. Camostat mesilate therapy for COVID-19

[5] Markus Hoffmann, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor