CD81 recombinant monoclonal antibody, clone 1D6

Western Blot

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunocytochemistry

Immunofluorescence

Immunofluorescenct staining of Jurkat cells with CD81 recombinant monoclonal antibody, clone 1D6 (Cat # RAB03346).
Immunofluorescence analysis of paraformaldehyde Jurkat cells fixed on Shi-fix™ coverslips, permeabilized with 0.15% Triton stained with the chimeric mouse IgG1 version of RAB03346 at 10 ug/mL for 1h followed by Alexa Fluor® 488 secondary antibody (2 ug/mL), showing membrane staining. The nuclear stain is DAPI (blue). The isotype control was stained with an unknown specificity antibody followed by Alexa Fluor® 488 secondary antibody.

Immunoprecipitation

Enzyme-linked Immunoabsorbent Assay

Functional Study

Flow Cytometry

Entrez GeneID

975

Gene Name

CD81

Gene Alias

S5.7, TAPA1, TSPAN28

Gene Description

CD81 molecule

Omim ID

186845

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. [provided by RefSeq

Other Designations

26 kDa cell surface protein TAPA-1|CD81 antigen|CD81 antigen (target of antiproliferative antibody 1)|target of antiproliferative antibody 1