Glutarimide antibiotic isolated from Streptomyces griseus; active against fungi and yeasts, but not against bacteria. Inhibits eukaryotic protein synthesis by blocking the translocation step in the elongation cycle (1,3,8). Blocks translation of mRNA on cytosolic but not on mitochondrial or chloroplast ribosomes (2,4,6).

Assay (HPLC) MP

min. 90.0 % 98 - 112 °C

Actidione = registered trademark of Upjohn.


References:

1. McKeehan, W. & Hardesty, B. (1969) Biochem. Biophys. Res. Commun. 36, 625-30
2. Neupert, W. et al. (1969) Eur. J. Biochem. 10, 589-91
3. Obrig, T.G. et al. (1971) J. Biol. Chem. 246, 174-81
4. Avadhani, N.G. & Buetow, D.E. (1972) Biochem. J. 128, 353-65
5. Jilek, F. et al. (2000) Animal Reprod. Sci. 63, 101-11
6. Hanten, J.J. & Pierce, S.K. (2001) Biol. Bull. 201, 34-44
7. Jin, S. et al. (2008) Am. J. Physiol. 294, G928-37
8. Schneider-Poetsch, T. et al. (2010) Nat. Chem. Biol. 6, 209-17

DANGER

Hazard Statements	H300 - H341 - H360D - H411
Precautions	P201 - P264 - P273 - P280
Reaction	P301 +P310 - P330

Muta. 2, Repr. 1B • EG-Index: 613-140-00-8 • GGVSE/ADR: 6.1 I UN2811 • IATA: 6.1 I UN2811 • EINECS: 200-636-0 • WGK: 3L • HS: 29419000
Storage Temperature: +2 °C to +8 °C