Duvelisib hydrate
Referência orb1738678-5mg
Tamanho : 5mg
Marca : Biorbyt
Duvelisib hydrate
Catalog Number: orb1738678
Catalog Number | orb1738678 |
---|---|
Category | Small Molecules |
Description | Duvelisib hydrate |
CAS Number | 1386861-49-9 |
Purity | 0.98 |
MW | 434.884 |
SMILES | O.C[C@H](Nc1ncnc2nc[nH]c12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1 |
Formula | C22H19ClN6O2 |
Biological Activity | Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |