Estrogen-Related Receptor, alpha (ERRa, NR3B1, NR3 Steroid Receptor) (PE)
Referência E3565-13F-PE-100ul
Tamanho : 100ul
Marca : US Biological
E3565-13F-PE Rabbit Anti-Estrogen-Related Receptor, alpha (ERRa, NR3B1, NR3 Steroid Receptor) (PE)
Clone Type
PolyclonalHost
rabbitSource
humanSwiss Prot
P11474Isotype
IgGGrade
Affinity PurifiedApplications
IC WBCrossreactivity
Hu MoAccession #
NP_004442Shipping Temp
Blue IceStorage Temp
4°C Do Not FreezeERR alpha is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site specific transcription regulator and has also been shown to interact with estrogen and the transcription factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium chain acyl coenzyme A dehydrogenase (MCAD),and thyroid hormone receptor genes. ERR alpha is expressed in many adult and embryonic tissues (particularly at the onset of ossification) as well as in several osteoblast cell lines. ERR alpha expression has been documented in brain, spinal cord, pituitary gland and heart. More recently, ERR alpha has been observed in various human breast cancer cell lines, breast adipose tissue and breast tumors. Studies demonstrating the use of ERR alpha antagonists in treating breast cancer have excited great interest in this receptor in the search for curing the disease (Chisamore, 2009).||Applications: |Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. ||Recommended Dilution:|Western Blot: 2ug/ml|Immunocytochemistry: 1:500|Optimal dilutions to be determined by the researcher.||Positive Control:|HeLa cell lysate||Storage and Stability:|Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.||Note: Applications are based on unconjugated antibody.