Filaggrin antibody [FLG01]
Referência GTX23137-500ul
Tamanho : 500ul
Marca : Genetex
Contactar o distribuidor local :
Telefone : +1 850 650 7790
![Anti-Filaggrin antibody [FLG01] used in Western Blot (WB). GTX23137](http://www.genetex.com/templates/default/js/lightbox/images/loading.gif "Anti-Filaggrin antibody [FLG01] used in Western Blot (WB). GTX23137")
Host | Mouse |
|---|---|
Clonality | Monoclonal |
Clone Name | FLG01 |
Isotype | IgG1 |
Application | WB, ICC/IF, IHC-P, IHC-Fr |
Reactivity | Human, Mouse |
| Package | 500 μl |
Datasheet File View product citations for antibody GTX23137 on CiteAb
APPLICATION
Application Note
Immunohistochemistry (formalin fixed paraffin embedded): use at a concentration of 2 - 4μg / ml for 30 min at RT. Optimal dilutions / concentrations should be determined by the end user. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
Calculated MW
435 kDa. ( Note )
Positive Control
Skin
PROPERTIES
Form
Liquid
Buffer
PBS, 0.2% BSA
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant full length protein
Purification
Protein G purified
Conjugation
Unconjugated
RRID
AB_384952
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
filaggrin , ATOD2
Background
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
Database
DATA IMAGES
| | GTX23137 WB ImageThe data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303 |
| | GTX23137 IHC-Fr ImageThe data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303 |
| | GTX23137 IHC-Fr ImageThe data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303 |
| | GTX23137 WB ImageThe data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303 |
| | GTX23137 ImageThe data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303 |
| | GTX23137 ImageThe data was published in the journal J Allergy Clin Immunol in 2017.PMID: 27913303 |
| | GTX23137 ICC/IF ImageThe data was published in the journal Cell Death Dis in 2018. PMID: 29545605 |
Application Reference
Oh JS et al. Nutrients 2021; 13 (9) Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice.
Application : WB
Reactivity : Mouse
Gutowska-Owsiak D et al. Cell Death Dis 2018; 9 (4) : 412 Orchestrated control of filaggrin-actin scaffolds underpins cornification.
Application : ICC/IF
Reactivity : Human
Naeem AS et al. J Allergy Clin Immunol 2017; 139 (4) : 1228-1241 A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis.
Kolesnik M et al. Acta Derm Venereol 2017; : Epub ahead of print Eczema in Psoriatico: An Important Differential Diagnosis Between Chronic Allergic Contact Dermatitis and Psoriasis in Palmoplantar Localization.
Application : IHC-P
Reactivity : Human
Biedermann T et al. J Invest Dermatol 2010; 130 (8) : 1996-2009 Human eccrine sweat gland cells can reconstitute a stratified epidermis.
Application : ICC/IF
Reactivity : Human
REVIEW
Application Reference
Oh JS et al. Nutrients 2021; 13 (9) Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice.
Application : WB
Reactivity : Mouse
Gutowska-Owsiak D et al. Cell Death Dis 2018; 9 (4):412 Orchestrated control of filaggrin-actin scaffolds underpins cornification.
Application : ICC/IF
Reactivity : Human
Naeem AS et al. J Allergy Clin Immunol 2017; 139 (4):1228-1241 A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis.
Kolesnik M et al. Acta Derm Venereol 2017;:Epub ahead of print Eczema in Psoriatico: An Important Differential Diagnosis Between Chronic Allergic Contact Dermatitis and Psoriasis in Palmoplantar Localization.
Application : IHC-P
Reactivity : Human
Biedermann T et al. J Invest Dermatol 2010; 130 (8):1996-2009 Human eccrine sweat gland cells can reconstitute a stratified epidermis.
Application : ICC/IF
Reactivity : Human
| SDS | |
|---|---|
| PBS.pdf | |
| Sodium Azide.pdf | |
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