FOXN1 Antibody (OABF01764-100UL) : HRP
Referência OABF01764-HRP
Tamanho : 100ul
Marca : Aviva Systems Biology
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FOXN1 Antibody (OABF01764)
| Datasheets/Manuals | Printable datasheet for FOXN1 Antibody (OABF01764) |
|---|
| Tested Species Reactivity | Human, Mouse, Rat |
|---|---|
| Predicted Species Reactivity | Bovine|Chicken|Dog|Horse|Human|Mouse|Porcine|Rabbit|Rat |
| Product Format | Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | ELISA, FC, ICC, IHC-P, IP, WB |
| Additional Information | Subcellular location: Nucleus |
| Reconstitution and Storage | -20°C |
| Immunogen | KLH conjugated synthetic peptide derived from human FOXN1 |
| Purification | Protein A Purified |
| Concentration | 1 ug/ul |
| Application Info | WB: 1:300~1000 ELISA: 1:500~1000 FC: 1:20~100 IHC-P: 1:200~400 IHC-F: 1:100~500 Fluorescent-(IHC-P): 1:50~200 Fluorescent-(IHC-F): 1:50~200 Fluorescent-ICC: 1:50~200 |
| Gene Symbol | FOXN1 |
|---|---|
| Gene Full Name | forkhead box N1 |
| Alias Symbols | FKHL20;forkhead box protein N1;RONU;Rowett nude;TIDAND;TLIND;WHN;winged-helix nude;winged-helix transcription factor nude. |
| NCBI Gene Id | 8456 |
| Protein Name | Forkhead box protein N1 |
| Description of Target | Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891). |
| Uniprot ID | O15353 |
