GFAP (Glial Fibrillary Acidic Protein) (PE)

Referência 214855-PE-100ul

Tamanho : 100ul

Marca : US Biological

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214855-PE GFAP (Glial Fibrillary Acidic Protein) (PE)

Clone Type
Polyclonal
Host
mouse
Source
bovine
Swiss Prot
P14136, P47819, P03995, Q28115
Isotype
IgG2b
Grade
Affinity Purified
Applications
IHC RIA WB
Crossreactivity
Bo Ca Ch Gp Hu Mo Po Rb Rt Sh
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze

Glial fibrillary acidic protein, or GFAP, a class III intermediate filament. During development of the central nervous system, GFAP distinguishes astrocytes from other glial cells. It is involved in various cellular functions, such as cell structure and movement, cell communication and the functioning of the blood-brain barrier. It also plays a role in mitosis by adjusting the filament network present in the cell.||Defects in GFAP are a cause of Alexander disease, a rare disorder of the central nervous system affecting mostly males. It is a progressive leukoencephalopathy resulting in mental and physical retardation, dementia, seizures and early death.||Applications: |Suitable for use in RIA, Western Blot, Immunohistochemistry. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.||Note: Applications are based on unconjugated antibody.

Applications
Product Type: Mab|Isotype: IgG2b|Clone No: 2E1|Host: mouse|Source: bovine|Concentration: As Reported|Form: Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE).|Purity: Purified by Protein G affinity chromatography from tissue culture supernatant. |Immunogen: Bovine spinal cord homogenate.|Specificity: Recognizes bovine GFAP. Species Crossreactivity: Human, mouse, rat, sheep, canine, porcine, rabbit, guinea pig and chicken ||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
Bovine spinal cord homogenate.
Form
Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE).
Purity
Purified by Protein G affinity chromatography from tissue culture supernatant.
Specificity
Recognizes bovine GFAP. Species Crossreactivity: Human, mouse, rat, sheep, canine, porcine, rabbit, guinea pig and chicken
References
1. Pegram, C.N. et al. (1985) Monoclonal antibodies reactive with epitopes restricted to glial fibrillary acidic proteins of several species. Neurochem. Pathol. 3: 119-138. 2. McLendon, R.E. et al. (1986) The immunohistochemical application of three anti-GFAP monoclonal antibodies to formalin-fixed, paraffin-embedded, normal and neoplastic brain tissues. J. Neuropathol. Exp. Neurol. 45: 692-703.Bovine spinal cord homogenate.