GRM1 Antibody (OABF00837-100UL) : Biotin
Referência OABF00837-Biotin
Tamanho : 100ul
Marca : Aviva Systems Biology
Contactar o distribuidor local :
Telefone : +1 850 650 7790
GRM1 Antibody (OABF00837)
| Datasheets/Manuals | Printable datasheet for GRM1 Antibody (OABF00837) |
|---|
| Tested Species Reactivity | Human, Mouse, Rat |
|---|---|
| Predicted Species Reactivity | Bovine|Chicken|Dog|Horse|Human|Mouse|Porcine|Rat |
| Product Format | Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | ELISA, FC, ICC, IF, IHC-Fr, IHC-P, WB |
| Reconstitution and Storage | -20°C |
| Immunogen | KLH conjugated synthetic peptide derived from human GRM1 |
| Purification | Protein A Purified |
| Concentration | 1 ug/ul |
| Application Info | WB: 1:300~1000 ELISA: 1:500~1000 FC: 1:20~100 IHC-P: 1:200~400 IHC-F: 100~500 Fluorescent (IHC-P): 1:50~200 Fluorescent (IHC-F): 1:50~200 Fluorescent-ICC: 1:50~200 ICC: 1:100~500 |
| Gene Symbol | GRM1|GRM5 |
|---|---|
| Gene Full Name | glutamate metabotropic receptor 1|glutamate metabotropic receptor 5 |
| Alias Symbols | glutamate receptor, metabotropic 1;glutamate receptor, metabotropic 5;GPRC1A;GPRC1E;metabotropic glutamate receptor 1;metabotropic glutamate receptor 5;MGLU1;mGlu5;MGLUR1;MGLUR5;PPP1R85;PPP1R86;protein phosphatase 1, regulatory subunit 85;protein phosphatase 1, regulatory subunit 86;SCA44;SCAR13. |
| NCBI Gene Id | 2911|2915 |
| Description of Target | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq]. |
