GW280264X [866924-39-2]
Referência AOB3632-1
Tamanho : 1mg
Marca : AOBIOUS
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Data sheet
| Molecular Formula | C28H41N5O6S |
| Molecular Weight | 575.72 |
| CAS Numbers | 866924-39-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | 57.57mg/mL in DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | Phenylmethyl N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate |
| InChl Key | SKJLITFHSZNZMQ-SGNDLWITSA-N |
| SMILES Code | CCC[C@H](N(C=O)O)[C@H](C(N[C@H](C(NC1=NC=CS1)=O)CCCCNC(OCC2=CC=CC=C2)=O)=O)CC(C)C |
| References | 1) Hundhausen et al (2003) The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood 102 1186 PMID: 12714508 2) Sommer et al (2019) ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury Brain Behav.Immun. 80 129 PMID: 30851378 |
| PubChem ID | 91885425 |
More info
Inhibitor of of the metalloproteinase ADAM17; Inhibitor of the constitutive and the PMA-inducible CX3CL1 cleavage, blocking TACE as well as ADAM10