General Info
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.27ng/mL |
| Detection Limit: | 0.781-50ng/mL |
| Short Description: | This IMPDH2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
Information
| Gene Symbol: | IMPDH2 |
| Gene ID: | 3615 |
| Uniprot ID: | IMDH2_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
Description
| Tissue Specificity | IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor. |
| Post Translational Modifications | Ubiquitinated leading to its degradation by the proteasome. The N-terminus is blocked. Acetylated by CLOCK in a circadian manner. |
| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Protein Name | Inosine-5'-Monophosphate Dehydrogenase 2Imp Dehydrogenase 2Impd 2Impdh 2Inosine-5'-Monophosphate Dehydrogenase Type IiImp Dehydrogenase IiImpdh-Ii |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-73817Reactome: R-HSA-9679191Reactome: R-HSA-9748787 |
| Cellular Localisation | CytoplasmNucleusCytosolCan Form Fiber-Like Subcellular Structures Termed 'Cytoophidia' In Response To Intracellular Guanine-Nucleotide Depletion |
| Alternative ELISA Names | Inosine-5'-Monophosphate Dehydrogenase 2 ELISA kitImp Dehydrogenase 2 ELISA kitImpd 2 ELISA kitImpdh 2 ELISA kitInosine-5'-Monophosphate Dehydrogenase Type Ii ELISA kitImp Dehydrogenase Ii ELISA kitImpdh-Ii ELISA kitIMPDH2 ELISA kitIMPD2 ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance