Human PARP1 Antibody : APC (Cleaved-Asp214)
Referência OAAQ00198-10tests
Tamanho : 10Tests
Marca : Aviva Systems Biology
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Human PARP1 Antibody : APC (Cleaved-Asp214) (OAAQ00198)
| Datasheets/Manuals | Printable datasheet for OAAQ00198 |
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| Tested Species Reactivity | Human |
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| Predicted Species Reactivity | Mouse, Rat |
| Product Format | Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA. |
| Clonality | Monoclonal |
| Clone | PARP-H8 |
| Isotype | Rabbit IgG1k |
| Host | Rabbit |
| Conjugation | APC: Allophycocyanin |
| Application | FC |
| Reconstitution and Storage | 2-8C |
| Immunogen | A synthetic peptide corresponding to residues surrounding Asp214 of human PARP |
| Purification | Protein A+G |
| Target Post-Translational Modification | Cleaved-Asp214 |
| Application Info | For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Reference | Bressenot A, Marchal S, Bezdetnaya L, Garrier J, Guillemin F, and Plenat F. (2009) Journal of Histochemistry and Cytochemistry. 57: 289-300. Chaitanya GV, Alexander JS, and Babu, PP. (2010) Cell Communication and Signaling. 8:31. Kraus WL, and Lis JT. (2003) Cell. 113:677-683. |
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| Gene Symbol | PARP1 |
| Gene Full Name | poly(ADP-ribose) polymerase 1 |
| Alias Symbols | PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1 |
| NCBI Gene Id | 142 |
| Protein Name | poly [ADP-ribose] polymerase 1 |
| Description of Target | This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. |
| Uniprot ID | P09874 |
| Protein Accession # | NP_001609.2 |
| Nucleotide Accession # | NM_001618.3 |
