Human PIK3R3/PIK3R1/PIK3R2 Antibody : APC (Phospho-Tyr458/Tyr199)
Referência OAAQ00066-10tests
Tamanho : 10Tests
Marca : Aviva Systems Biology
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Human PIK3R3/PIK3R1/PIK3R2 Antibody : APC (Phospho-Tyr458/Tyr199) (OAAQ00066)
| Datasheets/Manuals | Printable datasheet for OAAQ00066 |
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| Tested Species Reactivity | Human, Mouse |
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| Predicted Species Reactivity | Mouse, Rat |
| Product Format | Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA. |
| Clonality | Monoclonal |
| Clone | PI3KY458-1A11 |
| Isotype | Rabbit IgG1k |
| Host | Rabbit |
| Conjugation | APC: Allophycocyanin |
| Application | FC |
| Reconstitution and Storage | 2-8C |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr458 of human phospho PI3K p85 |
| Purification | Protein A+G |
| Target Post-Translational Modification | Phospho-Tyr458/Tyr199 |
| Application Info | For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Reference | Franke TF, Kaplan DR, and Cantley LC. (1997) Cell. 88: 435-437. Fresno JAV, Casado E, Cejas P, et al. (2004) Cancer Treatment Reviews. 30: 193-204. |
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| Gene Symbol | PIK3R3, PIK3R1, PIK3R2 |
| Gene Full Name | phosphoinositide-3-kinase regulatory subunit 3, phosphoinositide-3-kinase regulatory subunit 1, phosphoinositide-3-kinase regulatory subunit 2 |
| Alias Symbols | p55, p55PIK, p55-GAMMA |
| NCBI Gene Id | 8503; 5295; 5296 |
| Protein Name | phosphatidylinositol 3-kinase regulatory subunit gamma, phosphatidylinositol 3-kinase regulatory subunit alpha, phosphatidylinositol 3-kinase regulatory subunit beta |
| Description of Target | Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Three transcript variants, one protein coding and the other two non-protein coding, have been found for this gene. |
| Uniprot ID | Q92569, P27986, O00459 |
| Protein Accession # | NP_001107644.1 |
| Nucleotide Accession # | NM_001114172.1 |
