Human TRPV1 (Transient Receptor Potential Cation Channel Subfamily V, Member 1) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	TRPV1
Gene ID:	7442
Uniprot ID:	TRPV1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).
Post Translational Modifications	Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.
Function	Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
Protein Name	Transient Receptor Potential Cation Channel Subfamily V Member 1 Trpv1 Capsaicin Receptor Osm-9-Like Trp Channel 1 Otrpc1 Vanilloid Receptor 1
Database Links	Reactome: R-HSA-3295583
Cellular Localisation	Postsynaptic Cell Membrane Multi-Pass Membrane Protein Cell Projection Dendritic Spine Membrane Cell Membrane Mostly But Not Exclusively Expressed In Postsynaptic Dendritic Spines
Alternative ELISA Names	Transient Receptor Potential Cation Channel Subfamily V Member 1 ELISA kit Trpv1 ELISA kit Capsaicin Receptor ELISA kit Osm-9-Like Trp Channel 1 ELISA kit Otrpc1 ELISA kit Vanilloid Receptor 1 ELISA kit TRPV1 ELISA kit VR1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance