Leflunomide

Referência M2229-100mg

Tamanho : 100mg

Marca : AbMole Bioscience

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Leflunomide Structure
Synonym:

HWA486; RS-34821; SU101


Quality Control & Documentation
Biological Activity

Leflunomide is an inhibitor of dihydroorotate dehydrogenase with IC50 of 2.5 μM. Leflunomide inhibits de novo pyrimidine synthesis in human T-cells in vitro. Leflunomide also inhibits lymphocyte proliferation. The inhibition of human DHODH by A77 1726, the active metabolite of leflunomide, occurs at levels (approximately 600 nM) that are achieved during treatment of rheumatoid arthritis (RA).

Chemical Information
Molecular Weight 270.21
Formula C12H9F3N2O2
CAS Number 75706-12-6
Solubility (25°C) DMSO 40 mg/mL
Ethanol 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Davis JP, et al. Biochemistry. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase.

[2] Xu X, et al. J Biol Chem. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide.