Mouse Anti-Human CD4-AF700
Referência 9522-27
Tamanho : 100tests
Marca : Southern Biotech
Clone | RFT4 |
---|---|
Isotype | Mouse (BALB/c) IgG1κ |
Isotype Control | Mouse IgG1-AF700 (15H6) |
Specificity | Human CD4 |
Alternative Names | T4, Leu-3 |
Description | CD4 is a 55 kDa type I transmembrane glycoprotein and a member of the Ig-SF of cell surface receptors. It is expressed predominantly on the “helper/inducer” subpopulation of mature T lymphocytes and on monocytes and macrophages. Domains 1 and 2 bind to MHC Class II antigens, while domains 3 and 4 may be involved in cis interactions with the CD3/TCR complex. CD4 functions as an accessory molecule in the recognition of foreign antigens in association with MHC class II antigens by T cells. |
Immunogen | Thymocytes and E-rosetted lymphocytes |
Conjugate | AF700 (Alexa Fluor® 700) |
Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
Clonality | Monoclonal |
Concentration | Lot specific |
Volume | 1.0 mL |
Recommended Storage | 2-8°C; Avoid exposure to light |
Trademark Information | Alexa Fluor® is a registered trademark of Thermo Fisher Scientific, Inc. or its subsidiaries |
Applications | Flow Cytometry – Quality tested 1,7-9 Immunohistochemistry-Frozen Sections – Reported in literature 3 Immunocytochemistry – Reported in literature 4,5 Western Blot – Reported in literature 2 Separation – Reported in literature 6 |
RRID Number | AB_2796859 |
Gene ID | 920 (Human) |
Gene ID Symbol | CD4 (Human) |
Gene ID Aliases | CD4mut |
UniProt ID | P01730 (Human |
UniProt Name | CD4_HUMAN (Human) |
Documentation
Technical Bulletin Safety Datasheet
Certificate of Analysis Lookup
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- 4. Poulter LW, Norris A, Powers C, Condez A, Burnes H, Schmekel B, et al. T cell dominated inflammatory reactions in the bronchioles of asymptomatic asthmatics are also present in the nasal mucosa. Postgrad Med J. 1991;67:747-53. (ICC)
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- 6. D'Acquisto F, Paschalidis N, Raza K, Buckley CD, Flower RJ, Perretti M. Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cells. Rheumatology. 2008;47:636-9. (Sep)
- 7. Daubenberger CA, Salomon M, Vecino W, Hübner B, Troll H, Rodriques R, et al. Functional and structural similarity of Vγ9V δ2 T cells in humans and Aotus monkeys, a primate infection model for Plasmodium falciparum malaria. J Immunol. 2001;167:6421-30. (FC)
- 8. Zariffard MR, Saifuddin M, Finnegan A, Spear GT. HSV type 2 infection increases HIV DNA detection in vaginal tissue of mice expressing human CD4 and CCR5. AIDS Res Hum Retroviruses. 2009;25:1157-64. (FC)
- 9. Roetynck S, Olotu A, Simam J, Marsh K, Stockinger B, Urban B, et al. Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure. PLoS One. 2013;8(1):e55195. (FC)