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Mouse Monoclonal Anti-CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) [Clone SPM489]
Referência NB-36-00559X-P0
Tamanho : 20ug
Marca : Neo Biotech
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Printable Datasheet
CD56 / NCAM1 (Neuronal Cell Marker) Antibody [SPM489]
Catalog Number Formulation Size Price
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-paraffin human Colon stained with CD56 MAb (SPM489)
Applications & Dilutions
Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml
Summary
This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.
Product Properties & Targets
Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Research Areas
Cardiovascular, Developmental Biology, Immunology, Neuroscience, Cytokine Signaling, Hematopoietic Stem Cells, Mesenchymal Stem Cell Differentiation, Neural Stem Cells, Signal Transduction, Stem Cell Differentiation
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane, Secreted
Gene Name
NCAM1
Positive Control
Cerebellum, Neuroblastoma, Pancreas
Immunogen
Membrane preparation of a small cell lung carcinoma
Alternate Names
Neural cell adhesion molecule 1, NCAM, Leu-19, NKH1, MSK39, NCAM120, NCAM140, NCAM180, Neural Cell Adhesion Molecule
Functions
- This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
- (Microbial infection) Acts as a receptor for rabies virus.
- (Microbial infection) Acts as a receptor for Zika virus.
Key References
- Gerardy-Schahn R; et. al. Int Journal of Cancer. Supplement, 1994, 8:38-42.
- Michalides R; et. al. International Journal of Cancer. Supplement, 1994, 8:34-7.
- K. Moolenaar et al.Cancer Research 50, 1102-1106, 1990
- Schol DJ; et. al. Int J Cancer. Supplement, 1988, 2:34-40
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/3253057/
- https://pubmed.ncbi.nlm.nih.gov/1710251/
- https://pubmed.ncbi.nlm.nih.gov/8075973/
- https://pubmed.ncbi.nlm.nih.gov/14702039/
- https://pubmed.ncbi.nlm.nih.gov/15489334/
- https://pubmed.ncbi.nlm.nih.gov/1339414/
- https://pubmed.ncbi.nlm.nih.gov/2887295/
- https://pubmed.ncbi.nlm.nih.gov/3203385/
- https://pubmed.ncbi.nlm.nih.gov/9696812/
- https://pubmed.ncbi.nlm.nih.gov/16335952/
- https://pubmed.ncbi.nlm.nih.gov/24275569/
- https://pubmed.ncbi.nlm.nih.gov/32753727/
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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