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N-Acetylneuraminic acid [131-48-6]

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Referência HY-I0400-100mg

Tamanho : 100mg

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Marca : MedChemExpress

Contactar o distribuidor local :

Telefone : +1 850 650 7790

N-Acetylneuraminic acid is a sialic acid monosaccharide ubiquitous on cell membrane glycoproteins and glycolipids of mammalian cell ganglioglycerides, which plays a biological role in neurotransmission, leukocyte vasodilation, and viral or bacterial infection.

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N-Acetylneuraminic acid Chemical Structure

CAS No. : 131-48-6

This product is a controlled substance and not for sale in your territory.

Based on 2 publication(s) in Google Scholar

Other Forms of N-Acetylneuraminic acid:

N-Acetylneuraminic acid-¹³C Obtenir un devis
N-Acetylneuraminic acid-¹³C-1 Obtenir un devis
N-Acetylneuraminic acid-¹³C-2 Obtenir un devis
N-Acetylneuraminic acid-¹³C-3 Obtenir un devis

Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

Masse moléculaire

309.27

Formule

C₁₁H₁₉NO₉

CAS No.

131-48-6

Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](NC(C)=O)[C@@H](O)CC(C(O)=O)=O

Structure Classification

Saccharides
Monosaccharides

Initial Source

Microorganisms

Endogenous metabolite

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvant et solubilité

In Vitro:

H₂O : 125 mg/mL (404.18 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2334 mL	16.1671 mL	32.3342 mL
5 mM	0.6467 mL	3.2334 mL	6.4668 mL
10 mM	0.3233 mL	1.6167 mL	3.2334 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (323.34 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureté et documentation

Purity: 99.44%

Select Batch:

Fiche technique (272 KB) SDS (393 KB)

COA (247 KB) HNMR (286 KB) RP-HPLC (218 KB) MS (69 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Bondioli L et al. PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid. Biomaterials. 2010 Apr;31(12):3395-403. [Content Brief]

[2]. Kiefel MJ, et al. Synthesis and biological evaluation of N-acetylneuraminic acid-based rotavirus inhibitors. J Med Chem. 1996 Mar 15;39(6):1314-20. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.2334 mL	16.1671 mL	32.3342 mL	80.8355 mL
	5 mM	0.6467 mL	3.2334 mL	6.4668 mL	16.1671 mL
	10 mM	0.3233 mL	1.6167 mL	3.2334 mL	8.0836 mL
	15 mM	0.2156 mL	1.0778 mL	2.1556 mL	5.3890 mL
	20 mM	0.1617 mL	0.8084 mL	1.6167 mL	4.0418 mL
	25 mM	0.1293 mL	0.6467 mL	1.2934 mL	3.2334 mL
	30 mM	0.1078 mL	0.5389 mL	1.0778 mL	2.6945 mL
	40 mM	0.0808 mL	0.4042 mL	0.8084 mL	2.0209 mL
	50 mM	0.0647 mL	0.3233 mL	0.6467 mL	1.6167 mL
	60 mM	0.0539 mL	0.2695 mL	0.5389 mL	1.3473 mL
	80 mM	0.0404 mL	0.2021 mL	0.4042 mL	1.0104 mL
	100 mM	0.0323 mL	0.1617 mL	0.3233 mL	0.8084 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

N-Acetylneuraminic acid Related Classifications

Anti-infection Metabolic Enzyme/Protease
Influenza Virus Endogenous Metabolite

N-Acetylneuraminic acid [131-48-6]

Referência HY-I0400-100mg

Contactar o distribuidor local :

Marca : MedChemExpress

Contactar o distribuidor local :

Other Forms of N-Acetylneuraminic acid:

Calculateur de molarité

Calculateur de dilution

Complete Stock Solution Preparation Table

N-Acetylneuraminic acid Related Classifications

Keywords:

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