NLRP3 Antibody
Referência OABF00351
Tamanho : 100ul
Marca : Aviva Systems Biology
Contactar o distribuidor local :
Telefone : +1 850 650 7790
NLRP3 Antibody (OABF00351)
| Datasheets/Manuals | Printable datasheet for NLRP3 Antibody (OABF00351) |
|---|
| Predicted Species Reactivity | Dog|Human|Mouse|Rat |
|---|---|
| Product Format | Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | ELISA, FC, ICC, IF, IHC-Fr, IHC-P, WB |
| Additional Information | Subcellular location: Cytoplasm, Nucleus, Secreted |
| Reconstitution and Storage | -20°C |
| Immunogen | KLH conjugated synthetic peptide derived from human NLRP3 |
| Purification | Protein A Purified |
| Concentration | 1 ug/ul |
| Application Info | WB: 1:300~1000 ELISA: 1:500~1000 FC: 1:20~100 ICC: 1:100~500 IHC-P: 1:200~400 IHC-F: 1:100~500 Fluorescent (IHC-P): 1:50~200 Fluorescent (IHC-F): 1:50~200 Fluorescent-ICC: 1:50~200 |
| Gene Symbol | NLRP3 |
|---|---|
| Gene Full Name | NLR family pyrin domain containing 3 |
| Alias Symbols | AGTAVPRL;AII;Angiotensin/vasopressin receptor AII/AVP-like;AVP;C1orf7;caterpiller protein 1.1;CIAS1;CLR1.1;cold autoinflammatory syndrome 1 protein;cold-induced autoinflammatory syndrome 1 protein;cryopyrin;cryopyrin, NACHT, LRR and PYD domains - containing protein 3;deafness, autosomal dominant 34;DFNA34;FCAS;FCAS1;FCU;KEFH;MWS;NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3;NACHT, LRR and PYD containing protein 3;NACHT, LRR and PYD domains-containing protein 3;NALP3;nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3;PYPAF1;PYRIN-containing APAF1-like protein 1. |
| NCBI Gene Id | 114548 |
| Protein Name | NACHT, LRR and PYD domains-containing protein 3 |
| Description of Target | As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. However, it is unclear what constitutes the direct NLRP3 activator. Activation in presence of cytosolic dsRNA is mediated by DHX33 (PubMed:23871209). Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). |
| Uniprot ID | Q96P20 |
