Biological Activity

Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Eukaryotic cells respond to the presence of oxaliplatin adducts in DNA by activating signal transduction pathways that result in cell cycle arrest, an increase in DNA repair activity and apoptosis. Oxaliplatin was found to be active against C32 and G361 cell lines with IC50 values of 49.48 and 9.07 μM (1 h exposure), 9.47 and 1.30 μM (4 h exposure), and 0.98 and 0.14 μM (24 h exposure), respectively.

DMSO can inactivate Oxaliplatin's activity

Product Citations

• 

  Dokl Biochem Biophys. 2023 Oct.

  Dichotomic Role of Low-Concentration EGCG in the Oxaliplatin Sensitivity of Colorectal Cancer Cells
  Oxaliplatin purchased from AbMole

Chemical Information

Molecular Weight	397.29
Formula	C8H14N2O4Pt
CAS Number	61825-94-3
Solubility (25°C)	Water 3 mg/mL warmed DMF 1.6 mg/mL
Storage	4°C, protect from light, sealed

References

[1] Matthew D Hall, et al. Cancer Res. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes