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> Pifithrin mu [64984-31-2]

Pifithrin mu [64984-31-2]

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Referência 10-1180-5mg

Tamanho : 5mg

Marca : Focus Biomolecules

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Pifithrin µ | HSP70 inhibitor

CAS:
64984-31-2
Catalog Number:
10-1180
Activity:
HSP70 inhibitor
Alternate Names:
PES, NSC-303580
Chemical Name:
2-Phenylethynesulfonamide
Molecular Weight:
181.21
Molecular Formula:
C8H7NO2S
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

size : Quantity 
10 mg$45.00
50 mg$170.00
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Pifithrin μ (64984-31-2) selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. Inhibits p53 binding to antiapoptotic proteins Bcl-xL and Bcl-2. Pifithrin μ rescues primary mouse thymocytes from P53-mediated apoptosis induced by radiation. Cell permeable.

References/Citations:

1) Leu et al. (2009), The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53; Mol. Cell, 36 15
2) Strom et al. (2006), Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.; Nat. Chem. Biol., 2 474

CAS:
64984-31-2
Catalog Number:
10-1180
Activity:
HSP70 inhibitor
Alternate Names:
PES, NSC-303580
Chemical Name:
2-Phenylethynesulfonamide
Molecular Weight:
181.21
Molecular Formula:
C8H7NO2S
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

Pifithrin μ (64984-31-2) selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. Inhibits p53 binding to antiapoptotic proteins Bcl-xL and Bcl-2. Pifithrin μ rescues primary mouse thymocytes from P53-mediated apoptosis induced by radiation. Cell permeable.

References/Citations:

1) Leu et al. (2009), The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53; Mol. Cell, 36 15
2) Strom et al. (2006), Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.; Nat. Chem. Biol., 2 474

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