A1018-5mg | Platelet Membrane Glycoprotein IIB Peptide (296-306) Clinisciences

Background

Human alloantisera specific for either the Bak' or Bakb allele have been shown to react exclusively with the heavy chain of membrane glycoprotein (GP) Ilb.

GPllb is composed of a 125 Kd heavy chain that is disulfide-linked to a 23 Kd light chain. Hydropathicity analysis of the cDNA sequence indicates that GPllb is anchored to the platelet through a single transmembrane domain located within 20 amino acids of the C-terminus of the light chain.

The GPllb-IIa complex is a Ca²⁺-dependent heterodimer that, on activated platelets, can bind one of the four different adhesive proteins. (i.e. fibrinogen, fibronectin, von Willebrand factor, or vitronectin ).

Ref:

1. Bray PF, Rosa J-P, Lingappa VR, Kan YW, McEver RP, Shuman MA: Biogenesis of the platelet receptor for fibrinogen: Evidence for separate precursors for glycoproteins Ilb and IIIa. Proc Natl Acad Sci USA 83:1480,1986

2. Silver SM, McDonough MM, Vilaire G, Bennett JS: The in vitro synthesis of polypeptides for the platelet membrane glycoproteins IIb and IIIa. Blood 69:1031, 1987.

3. Phillips DR, Charo IF, Parise LV, Fitzgerald LA : The platelet membrane glycoproteins IIb-IIIa co,plex. Blood 71:831-843, 1988

Product Citation

1. Feng Wang, Kai-Rui Feng, et al. "Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study." Bioorg Med Chem. 2020 Oct 22;28(24):115822. PMID: 33126089

Chemical Properties

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	1198.2
Formula	C₄₇H₇₅N₁₇O₂₀
Synonyms	H2N-Thr-Asp-Val-Asn-Gly-Asp-Gly-Arg-His-Asp-Leu-OH
Solubility	≥119.8 mg/mL in DMSO; ≥5 mg/mL in EtOH with ultrasonic; ≥50 mg/mL in H2O
SDF	Download SDF
Canonical SMILES	N[C@@H]([C@H](C)O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Purity = 98.92%

Platelet Membrane Glycoprotein IIB Peptide (296-306)

Referência A1018-5mg

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Background

Product Citation

Chemical Properties

Quality Control