Prazosin

Referência M5894-10mg

Tamanho : 10mg

Marca : AbMole Bioscience

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Prazosin  Structure

Quality Control & Documentation
Biological Activity

Prazosin is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders. Prazosin potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM. Prazosin inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13 μM, respectively.

Chemical Information
Molecular Weight 383.4
Formula C19H21N5O4
CAS Number 19216-56-9
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] De Berardis D, et al. Curr Drug Targets. Targeting the Noradrenergic System in Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis of Prazosin Trials.