Presenilin 1 (PSEN1) Human shRNA Plasmid Kit (Locus ID 5663)
Referência TL320496
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Presenilin 1 (PSEN1) Human shRNA Plasmid Kit (Locus ID 5663)
SKU
TL320496
PSEN1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
2 Weeks*
| Product Data | |
| Locus ID | 5663 |
|---|---|
| Synonyms | ACNINV3; AD3; FAD; PS-1; PS1; S182 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Format | Lentiviral plasmids |
| Components | PSEN1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 5663). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_000021, NM_007318, NM_007319, NM_000021.1, NM_000021.2, NM_000021.3, NM_007318.1, NM_007318.2, BC011729, BC002708, NM_000021.4, NM_007318.3 |
| UniProt ID | P49768 |
| Summary | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact tech@clinisciences.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.