RET Split FISH Probe (V.2)

Fluorescent In Situ Hybridization (Cell)

Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)

Human lung, adenosquamous cell carcinoma (FFPE) stained with RET Split FISH Probe. Huma lung, adenosquamous cell carcinoma showed no RET gene split.

Entrez GeneID

5979

Gene Name

RET

Gene Alias

CDHF12, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51

Gene Description

ret proto-oncogene

Omim ID

142623 155240 162300 164761 171300 171400 209880

Gene Ontology

Hyperlink

Gene Summary

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq

Other Designations

RET transforming sequence|cadherin family member 12|hydroxyaryl-protein kinase|oncogene RET|receptor tyrosine kinase|ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)