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> Sulfosuccinimidyl oleate sodium [1212012-37-7]

Sulfosuccinimidyl oleate sodium [1212012-37-7]

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Referência T13036L-5mg

Tamanho : 5mg

Marca : TargetMol

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Sulfosuccinimidyl oleate sodium

Sulfosuccinimidyl oleate sodium
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Purity:98.96%
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COA HPLC HNMR

Sulfosuccinimidyl oleate sodium

Catalog No. T13036LCas No. 1212012-37-7
Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia.
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Product Introduction

Bioactivity
Description
Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia.
In vitro
Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1].
In vivo
In male BALB/cABom mice with pMCAo model, Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls. In addition, Sulfosuccinimidyl oleate(50 mg/kg) is suitable to see a beneficial effect after stroke[1].
AliasSulfo-N-succinimidyl oleate sodium
Chemical Properties
Molecular Weight481.58
FormulaC22H36NNaO7S
Cas No.1212012-37-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 70 mg/mL (145.35 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0765 mL10.3825 mL20.7650 mL103.8249 mL
5 mM0.4153 mL2.0765 mL4.1530 mL20.7650 mL
10 mM0.2076 mL1.0382 mL2.0765 mL10.3825 mL
20 mM0.1038 mL0.5191 mL1.0382 mL5.1912 mL
50 mM0.0415 mL0.2076 mL0.4153 mL2.0765 mL
100 mM0.0208 mL0.1038 mL0.2076 mL1.0382 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify

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Tech Support

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Keywords

Sulfosuccinimidyl oleate sodium