Tim4, CT (T Cell Immunoglobulin and Mucin Domain Containing Protein 4, FLJ27515, T-cell Membrane Protein 4, TIM4, TIMD-4, TIMD4) (APC)

Referência 146090-APC-100ul

Tamanho : 100ul

Marca : US Biological

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146090-APC Tim4, CT (T Cell Immunoglobulin and Mucin Domain Containing Protein 4, FLJ27515, T-cell Membrane Protein 4, TIM4, TIMD-4, TIMD4) (APC)

Clone Type
Polyclonal
Host
rabbit
Source
human
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu Mo Rt
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze

TIM-4, also known as SMUCKLER is a 42kD type I membrane protein which is preferentially expressed on macrophages and dendritic cells. TIM-4 is the ligand of TIM-1, and binding leads to T-cell proliferation and cytokine production. Polymorphisms in the TIM-4 gene may be associated with a predisposition to asthma.||Applications: |Suitable for use in Western Blot. Other applications not tested.||Recommended Dilution:|Western Blot: 1-2ug/ml|Optimal dilutions to be determined by the researcher.||Storage and Stability:|Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. ||Note: Applications are based on unconjugated antibody.

Applications
Product Type: Pab|Isotype: IgG|Host: rabbit|Source: human|Concentration: As reported|Form: Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).|Purity: Purified by immunoaffinity chromatography.|Immunogen: Synthetic peptide corresponding to 15aa from near the C-terminus of human TIM-4.|Specificity: Recognizes human TIM-4. Species Crossreactivity: mouse and rat.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
Synthetic peptide corresponding to 15aa from near the C-terminus of human TIM-4.
Form
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human TIM-4. Species Crossreactivity: mouse and rat.
References
1. Meyers, J.H. et al. (2005) TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat. Immunol. 6: 455-464. 2. Meyers JH, et al. (2005) The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med. 11: 362-369.