A1123-1mg | Amyloid Beta-Peptide (12-28) (human) [107015-83-8] Clinisciences

Background

Amyloid beta (Aβ or Abeta) is a peptide of 36–43 amino acids that is processed from the Amyloid precursor protein. While best known as a component of amyloid plaques in association with Alzheimer's disease, evidence has been found that Aβ is a highly multifunctional peptide with significant non-pathological activity⁽¹⁾. Aβ is the main component of deposits found in the brains of patients with Alzheimer's disease. Brain Aβ is elevated in patients with sporadic Alzheimer’s disease. Aβ is the main constituent of brain parenchymal and vascular amyloid, it contributes to cerebrovascular lesions and is neurotoxic⁽²⁾.

A1123_1

Figure1 Formula of Amyloid β-Peptide (12-28) (human)

A1123_2

Figure2 signal pathway of Amyloid β

Ref:

1. Lahiri DK, Maloney B (September 2010). "Beyond the signaling effect role of amyloid–β42 on the processing of AβPP, and its clinical implications". Exp. Neurol. 225 (1): 51–4.

2. Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (September 1998). "Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau". Nat. Neurosci. 1 (5): 355–8.

Chemical Properties

Physical Appearance	A solid
Storage	Desiccate at -20°C
M.Wt	1955.2
Cas No.	107015-83-8
Formula	C₈₉H₁₃₅N₂₅O₂₅
Synonyms	Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys
Solubility	≥195.5 mg/mL in DMSO; insoluble in EtOH; ≥59.8 mg/mL in H2O
SDF	Download SDF
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Purity = 99.46%

Amyloid Beta-Peptide (12-28) (human) [107015-83-8]

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Background

Chemical Properties

Quality Control

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