BMS-536924 [468740-43-4]
Referência HY-10262-5mg
Tamanho : 5mg
Marca : MedChemExpress
BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
BMS-536924 Chemical Structure
CAS No. : 468740-43-4
This product is a controlled substance and not for sale in your territory.
Based on 3 publication(s) in Google Scholar
Description |
BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity[1][2]. |
IC50 & Target |
IC50: 100 nM (IGF-1R) and 73 nM (IR)[1][2] |
||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
In Vitro |
BMS-536924 inhibits FAK and Lck with IC50s of 150 nM and 341 nM, respectively[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
Cell Viability Assay[2]
Apoptosis Analysis[2]
Cell Cycle Analysis[2]
Western Blot Analysis[2]
|
||||||||||||||||||||||||||||||||||||||||
In Vivo |
BMS-536924 (100 mg/kg; gavage; daily; for 35 days) causes regression of xenografts in vivo and an average reduction of 76% tumor volume after 2 weeks[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
|
||||||||||||||||||||||||||||||||||||||||
Masse moléculaire |
479.96 |
||||||||||||||||||||||||||||||||||||||||
Formule |
C25H26ClN5O3 |
||||||||||||||||||||||||||||||||||||||||
CAS No. |
468740-43-4 |
||||||||||||||||||||||||||||||||||||||||
Appearance |
Solid |
||||||||||||||||||||||||||||||||||||||||
Color |
Light yellow to yellow |
||||||||||||||||||||||||||||||||||||||||
SMILES |
O=C1C(C2=NC3=CC(N4CCOCC4)=CC(C)=C3N2)=C(C=CN1)NC[C@@H](O)C5=CC=CC(Cl)=C5 |
||||||||||||||||||||||||||||||||||||||||
Livraison | Room temperature in continental US; may vary elsewhere. |
||||||||||||||||||||||||||||||||||||||||
Stockage |
|
||||||||||||||||||||||||||||||||||||||||
Solvant et solubilité |
In Vitro:
DMSO : 10 mg/mL (20.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
|
||||||||||||||||||||||||||||||||||||||||
Pureté et documentation |
Purity: 99.83% |
||||||||||||||||||||||||||||||||||||||||
Références |
|
Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
---|
DMSO | 1 mM | 2.0835 mL | 10.4175 mL | 20.8351 mL | 52.0877 mL |
5 mM | 0.4167 mL | 2.0835 mL | 4.1670 mL | 10.4175 mL | |
10 mM | 0.2084 mL | 1.0418 mL | 2.0835 mL | 5.2088 mL | |
15 mM | 0.1389 mL | 0.6945 mL | 1.3890 mL | 3.4725 mL | |
20 mM | 0.1042 mL | 0.5209 mL | 1.0418 mL | 2.6044 mL |