Copanlisib [1032568-63-0]
Referência HY-15346-5mg
Tamanho : 5mg
Marca : MedChemExpress
Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity.
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Copanlisib Chemical Structure
CAS No. : 1032568-63-0
This product is a controlled substance and not for sale in your territory.
Based on 25 publication(s) in Google Scholar
Other Forms of Copanlisib:
- Copanlisib dihydrochloride Obtenir un devis
- Copanlisib (Standard) Obtenir un devis
Voir tous les produits spécifiques à Isoform PI3K:
Description |
Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity[1]. |
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IC50 & Target[1] |
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Cellular Effect |
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In Vitro |
Copanlisib (BAY 80-6946; 20-200 nM; 24 hours; BT20 breast cancer cells) treatmemnt induces apoptosis in a subset of tumor cell lines that are resistant to Lapatinib and Trastuzumab[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis Analysis[1]
Western Blot Analysis[1]
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In Vivo |
Copanlisib (BAY 80-6946; 0.5-6 mg/kg; intravenous injection; every second day, every third day; for 60 days; athymic nude rats) treatment displays robust antitumor activity in the rat KPL4 tumor xenograft model[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Essai clinique |
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Masse moléculaire |
480.52 |
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Formule |
C23H28N8O4 |
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CAS No. |
1032568-63-0 |
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Appearance |
Solid |
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SMILES |
O=C(C1=CN=C(N)N=C1)NC2=NC3=C(OC)C(OCCCN4CCOCC4)=CC=C3C5=NCCN25 |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
1M HCl : 100 mg/mL (208.11 mM; Need ultrasonic) 1M HCl : 100 mg/mL (208.11 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
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Pureté et documentation |
Purity: 99.50% |
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Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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1M HCl / 1M HCl | 1 mM | 2.0811 mL | 10.4054 mL | 20.8108 mL | 52.0270 mL |
5 mM | 0.4162 mL | 2.0811 mL | 4.1622 mL | 10.4054 mL | |
10 mM | 0.2081 mL | 1.0405 mL | 2.0811 mL | 5.2027 mL | |
15 mM | 0.1387 mL | 0.6937 mL | 1.3874 mL | 3.4685 mL | |
20 mM | 0.1041 mL | 0.5203 mL | 1.0405 mL | 2.6013 mL | |
25 mM | 0.0832 mL | 0.4162 mL | 0.8324 mL | 2.0811 mL | |
30 mM | 0.0694 mL | 0.3468 mL | 0.6937 mL | 1.7342 mL | |
40 mM | 0.0520 mL | 0.2601 mL | 0.5203 mL | 1.3007 mL | |
50 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0405 mL | |
60 mM | 0.0347 mL | 0.1734 mL | 0.3468 mL | 0.8671 mL | |
80 mM | 0.0260 mL | 0.1301 mL | 0.2601 mL | 0.6503 mL | |
100 mM | 0.0208 mL | 0.1041 mL | 0.2081 mL | 0.5203 mL |
Copanlisib Related Classifications
- PI3K/Akt/mTOR Apoptosis
- PI3K Apoptosis