GENIUS™ Nuclease [9025-65-4]

Referência sc-202391

Tamanho : 25KU

Marca : Santa Cruz Biotechnology

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GENIUS™ Nuclease (CAS 9025-65-4)

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Application:
Numéro CAS:
9025-65-4
Pureté:
≥90%
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
* Consulter le Certificat d'Analyses pour les données spécifiques à un lot (incluant la teneur en eau).

ACCÈS RAPIDE AUX LIENS

GENIUS™ Nuclease is an engineered enzyme tailored for genome editing applications in molecular biology and genetic research. This tool is specifically designed to enhance the precision and efficiency of DNA manipulation by targeting and cleaving specific sequences within the genome. Its mechanism involves the recognition of designated DNA regions followed by the introduction of double-stranded breaks, facilitating targeted genetic modifications such as gene knockouts, insertions, and tagging. The use of GENIUS™ Nuclease in research allows scientists to precisely edit the genetic material, enabling the exploration of gene functions, the study of genetic disorders, and the development of genetically modified organisms. This nuclease′s ability to execute precise genetic alterations significantly contributes to advancements in genetic engineering by improving the accuracy, reliability, and speed of experimental outcomes. It stands as a critical asset in the field of genetic research, providing researchers with the capability to perform complex genetic rearr

References:

  1. Disulfide bonds are required for Serratia marcescens nuclease activity.  |  Ball, TK., et al. 1992. Nucleic Acids Res. 20: 4971-4. PMID: 1329033
  2. The extracellular nuclease gene of Serratia marcescens and its secretion from Escherichia coli.  |  Ball, TK., et al. 1987. Gene. 57: 183-92. PMID: 3319779
  3. 2.1 A structure of Serratia endonuclease suggests a mechanism for binding to double-stranded DNA.  |  Miller, MD., et al. 1994. Nat Struct Biol. 1: 461-8. PMID: 7664065
  4. A new mass spectrometric approach to detect modifications in DNA.  |  Janning, P., et al. 1994. Rapid Commun Mass Spectrom. 8: 1035-40. PMID: 7696699
  5. Identification of catalytically relevant amino acids of the extracellular Serratia marcescens endonuclease by alignment-guided mutagenesis.  |  Friedhoff, P., et al. 1994. Nucleic Acids Res. 22: 3280-7. PMID: 8078761
  6. Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis.  |  Molloy, MP., et al. 1998. Electrophoresis. 19: 837-44. PMID: 9629924
  7. Improved protein solubility in two-dimensional electrophoresis using tributyl phosphine as reducing agent.  |  Herbert, BR., et al. 1998. Electrophoresis. 19: 845-51. PMID: 9629925

Informations pour la commande

Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

GENIUS™ Nuclease, 25 KU

sc-202391
25 KU
.00

GENIUS™ Nuclease, 500 KU

sc-202391A
500 KU
1.00

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