Human HDAC1 (Histone Deacetylase 1) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	HDAC1
Gene ID:	3065
Uniprot ID:	HDAC1_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
Post Translational Modifications	Sumoylated on Lys-444 and Lys-476.which promotes enzymatic activity. Desumoylated by SENP1. Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5. Ubiquitinated by CHFR, leading to its degradation by the proteasome. Ubiquitinated by KCTD11, leading to proteasomal degradation.
Function	Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Also functions as deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3 and TSHZ3. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.
Protein Name	Histone Deacetylase 1 Hd1 Protein Deacetylase Hdac1 Protein Decrotonylase Hdac1
Database Links	Reactome: R-HSA-1362277 Reactome: R-HSA-1362300 Reactome: R-HSA-1538133 Reactome: R-HSA-193670 Reactome: R-HSA-201722 Reactome: R-HSA-2122947 Reactome: R-HSA-2173795 Reactome: R-HSA-2173796 Reactome: R-HSA-2644606 Reactome: R-HSA-2894862 Reactome: R-HSA-3214815 Reactome: R-HSA-350054 Reactome: R-HSA-3769402 Reactome: R-HSA-427389 Reactome: R-HSA-427413 Reactome: R-HSA-4551638 Reactome: R-HSA-4641265 Reactome: R-HSA-6804758 Reactome: R-HSA-69205 Reactome: R-HSA-73762 Reactome: R-HSA-8936459 Reactome: R-HSA-8943724 Reactome: R-HSA-9018519 Reactome: R-HSA-9022538 Reactome: R-HSA-9022692 Reactome: R-HSA-9022699 Reactome: R-HSA-9022702 Reactome: R-HSA-9615017 Reactome: R-HSA-9679191 Reactome: R-HSA-9701898 Reactome: R-HSA-983231
Cellular Localisation	Nucleus
Alternative ELISA Names	Histone Deacetylase 1 ELISA kit Hd1 ELISA kit Protein Deacetylase Hdac1 ELISA kit Protein Decrotonylase Hdac1 ELISA kit HDAC1 ELISA kit RPD3L1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance