Mouse Monoclonal Anti-Tenascin C (Stromal Marker For Epithelial Malignancy) [Clone SPM319]
Referência NB-36-00304X-P1
Tamanho : 100ug
Marca : Neo Biotech
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Tenascin C (Stromal Marker for Epithelial Malignancy) Antibody [SPM319]
Applications & Dilutions
Summary
In Western blotting, it reacts with two bands of ~MW of 210kDa and 300kDa, identified as two isoforms of Tenascin C. Specificity of this MAb is validated by sequential immunoprecipitation with a PAb against Tenascin C. Tenascin C is a multifunctional, disulfide-linkedhexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neo-vasculature and stroma of undifferentiated tumors. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyper-proliferative diseases and in stroma of many neoplasms, including gliomas, breast, squamous and lung carcinomas.
Product Properties & Targets
Functions
- Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
Key References
- Verstraeten AA, et. al. British Journal of Dermatology, 1992, 127(6):571-4.
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/1704365/
- https://pubmed.ncbi.nlm.nih.gov/1707164/
- https://pubmed.ncbi.nlm.nih.gov/1719530/
- https://pubmed.ncbi.nlm.nih.gov/7531707/
- https://pubmed.ncbi.nlm.nih.gov/15164053/
- https://pubmed.ncbi.nlm.nih.gov/7524681/
- https://pubmed.ncbi.nlm.nih.gov/2466295/
- https://pubmed.ncbi.nlm.nih.gov/8824254/
- https://pubmed.ncbi.nlm.nih.gov/16335952/
- https://pubmed.ncbi.nlm.nih.gov/18780401/
- https://pubmed.ncbi.nlm.nih.gov/19159218/
- https://pubmed.ncbi.nlm.nih.gov/19884327/
- https://pubmed.ncbi.nlm.nih.gov/21269460/
- https://pubmed.ncbi.nlm.nih.gov/24275569/
- https://pubmed.ncbi.nlm.nih.gov/26091039/
- https://pubmed.ncbi.nlm.nih.gov/1279805/
- https://pubmed.ncbi.nlm.nih.gov/23936043/
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