Reagentes e instrumentos para imunologia, biologia celular e biologia molecular.
 
> Phospho-PLCg2 (Tyr759) (Clone: G3) rabbit mAb FITC conjugate

Phospho-PLCg2 (Tyr759) (Clone: G3) rabbit mAb FITC conjugate

Imprimir Imprimir
Please log in

Referência 12-4027-10

Tamanho : 10Testss

Marca : Abeomics

Solicitar mais informações

Contactar o distribuidor local :


Telefone : +1 850 650 7790

Phospho-PLCg2 (Tyr759) (Clone: G3) rabbit mAb FITC conjugate

Fig-1: Flow cytometric analysis of Hela cells unstained cells negative control (blue) or stained and treated with imatinib (red) or treated with pervanadate (green) using Phospho-PLCg2 (Tyr759) FITC conjugate antibody PLCG2Y759-G3.

Available Pack Size(s)

  •   10 Tests

  •  100 Tests

  •  

  •  

Format : Conjugated
Amount : 100 Tests
Isotype : Rabbit IgG1k
Content : 1X PBS, 0.09% NaN3, 0.2% BSA
Storage condition : Store at 2-8°C. Avoid repeated freeze and thaw cycles.
Alternative Name : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, Phosphoinositide phospholipase C-gamma-2, PLC-IV, PLC-gamma-2, PLCG2
Immunogen Information : A synthetic phospho-peptide corresponding to residues surrounding Tyr759 of human phospho PLCg2.
The PLC-gamma isoforms of the PI-PLC family of lipases are regulated by growth factor receptors and B- and T-cell antigen receptors. While PLCg1 is expressed ubiquitously, PLCg2 is predominantly expressed in liver cells. PLCg2 plays a dominant role in B-cell signaling. Btk directly phosphorylates PLCg2, though the Syk kinase and BLNK adaptor protein are required. Both Tyr753 and Tyr759 have been identified as important phosphorylation sites for PLCg2 activation in B-cells. PLCg2 missense mutations and genomic deletions have been identified autoinflammatory diseases in humans. These include gain-of-function mutations, such as S707T, that possibly introduce an additional phosphorylation site and increase basal PLCg2 activity.

For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

There are currently no product reviews
Write a review on this product!