TH5487
Referência M9506-5mg
Tamanho : 5mg
Marca : AbMole Bioscience
All AbMole products are for research use only, cannot be used for human consumption.
TH-5487
Quality Control & Documentation
Biological Activity
TH5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 (5 μM; 1 hour) decreases TNFα- and LPS-induced proinflammatory gene expression to near pretreatment levels. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes.
In vivo, TH5487 (prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours) decreases TNFα or LPS induced the robust recruitment of neutrophils to the airways, and reduces the pulmonary neutrophil count in a time-dependent manner.
Chemical Information
Molecular Weight | 541.18 |
Formula | C19H18BrIN4O2 |
CAS Number | 2304947-71-3 |
Solubility (25°C) | DMSO ≥ 13 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
References
[1] Visnes T, et al. Science. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.