![EWSR1 probe for FISH CE/IVD - Salivary gland cancers](https://www.clinisciences.com/pt/upload/29-uxf8gb.png)
EWSR1 probe for FISH CE/IVD - Salivary gland cancers
EWSR1 (Ewing sarcoma breakpoint region 1) encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Translocations involving the chromosomal region 22q12.2 are found in 90-95% of patients with Ewing sarcoma or peripheral primitive neuroectodermal tumors (PNET). Ewing sarcoma is the second most common, highly malignant bone tumor in children and young adults. The most frequent translocation involving the EWSR1 gene region is t(11;22)(q24.3;q12.2)juxtaposing the EWSR1 gene in 22q12.2 next to the FLI-1 (friend leukemia virus integration 1) locus in 11q24.3. FLI-1 is a member of the ETS family of transcription factors. Less frequently, EWSR1 can also be fused to ERG, a transcription factor closely related to FLI-1 but located in 21q22.2. For prognosis and appropriate treatment it is important to differentiate Ewing sarcoma/PNET from classic neuroblastoma, Wilms tumor, and rhabdomyosarcoma. In combination with the histopathological diagnosis, detection of the EWSR1 rearrangements by FISH can be used to confirm the diagnosis of Ewing sarcoma/ PNET.
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RUOCE / IVD
- Green-Orange 2
- DIG-DNP 1
- Green-Orange-Blue 1
- Probe
- ISH 6
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