GLYcoDiag
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A GLYcoDiag é uma empresa de investigação e desenvolvimento especializada em glicociências que fornece serviços e produtos para as áreas da saúde (biomarcadores, glicoproteínas recombinantes terapêuticas, vacinas), cosmética (ingredientes activos, conceção e mecanismos de "glico-activos") e ambiente (biofilmes, águas residuais).
Desde 2015, a GLYcoDiag desenvolve a sua própria gama de reagentes e kits para fins de investigação:
Lectinas naturais e recombinantes
Neoglicoproteínas e neoglicoclusters
Géis LEctPROFILE®, géis CarbPROFILE Kits LEctPROFILE® (kits baseados em lectinas destinados ao rastreio / comparação / deteção de ligandos) Sítio Web: www.glycodiag.com
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![Narcissus pseudonarcissus Lectin (NPL/NPA)](https://www.clinisciences.com/pt/upload/thumbs/narcissus-pseudonarcissus-lent-li-mmaute-bb164f.jpg)
Narcissus pseudonarcissus Lectin (NPL/NPA)
Narcissus pseudonarcissus lectin or agglutinin (NPL/NPA) is isolated from wild daffodils. This lectin is composed of four subunits and has a molecular weight of 59 kDa. It agglutinates rabbit erythrocytes but is non-reactive with human erythrocytes. NPA has an isoelectric point between pH 4.2 and pH 4.6 with a specific binding activity toward alpha-D-mannose, although studies have suggested that the purified lectin may have greater affinity for internal mannosyl residues than for nonreducing terminal units.
Human studies have found NPA to be nearly non-mitogenic, but it has been reported through an in vitro study that mitogenicity of NPA is age-related, with lymphoproliferative response of peripheral blood mononuclear cells (PBMC) in umbilical cord blood has a sevenfold increase than adult blood. NPA has also been found to be mitogenic for PBMC from lambs and not adult sheep.
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