GLYcoDiag
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A GLYcoDiag é uma empresa de investigação e desenvolvimento especializada em glicociências que fornece serviços e produtos para as áreas da saúde (biomarcadores, glicoproteínas recombinantes terapêuticas, vacinas), cosmética (ingredientes activos, conceção e mecanismos de "glico-activos") e ambiente (biofilmes, águas residuais).
Desde 2015, a GLYcoDiag desenvolve a sua própria gama de reagentes e kits para fins de investigação:
Lectinas naturais e recombinantes
Neoglicoproteínas e neoglicoclusters
Géis LEctPROFILE®, géis CarbPROFILE Kits LEctPROFILE® (kits baseados em lectinas destinados ao rastreio / comparação / deteção de ligandos) Sítio Web: www.glycodiag.com
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Sambucus nigra Lectin (SNA/EBL I+II)
Sambucus nigra lectin (EBL I+II, also known as SNA) is isolated from elderberry bark. This lectin has a molecular weight of 140 kDa and is composed of two ricin-related lectins. EBL I+II is a tetrameric glycoprotein with a recognition of the Neu5Ac(alpha2-6)Gal or GalNAc linkage in glycoconjugates.
EBL I+II is not blood group specific but it does agglutinate type A erythrocytes more strongly than either B or O cells. Trypsin treated erythrocytes react better than untreated cells. Neuraminidase treated erythrocytes react with this lectin due to the presence of terminal galactose resides.
EBL I is composed of an A-chain with enzymatic activity and a B-chain with carbohydrate-binding activity. EBL II consists only of carbohydrate-binding B-chains. EBL I+II induces caspase-dependent apoptosis at low concentrations (nM) order, leading to typical symptoms of cell death in sensitive cells. This effect seems independent from the catalytic activity of the A-chain, but depends on the carbohydrate binding B-chain.
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