General Info
Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-TIMP3 (24-211) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:100-1:500IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | TIMP3 |
Gene ID: | 7078 |
Uniprot ID: | TIMP3_HUMAN |
Immunogen Region: | 24-211 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-211 of human TIMP3 (NP_000353.1). |
Immunogen Sequence: | CTCSPSHPQDAFCNSDIVIR AKVVGKKLVKEGPFGTLVYT IKQMKMYRGFTKMPHVQYIH TEASESLCGLKLEVNKYQYL LTGRVYDGKMYTGLCNFVER WDQLTLSQRKGLNYRYHLGC NCKIKSCYYLPCFVTSKNEC LWTDMLSNFGYPGYQSKHYA CIRQKGGYCSWYRGWAPPDK SIINATDP |
Description
Function | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. |
Protein Name | Metalloproteinase Inhibitor 3Protein Mig-5Tissue Inhibitor Of Metalloproteinases 3Timp-3 |
Database Links | Reactome: R-HSA-114608 |
Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
Alternative Antibody Names | Anti-Metalloproteinase Inhibitor 3 antibodyAnti-Protein Mig-5 antibodyAnti-Tissue Inhibitor Of Metalloproteinases 3 antibodyAnti-Timp-3 antibodyAnti-TIMP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance