Captopril [62571-86-2]
Referência HY-B0368-500mg
Tamanho : 500mg
Marca : MedChemExpress
Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM.
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Captopril Chemical Structure
CAS No. : 62571-86-2
This product is a controlled substance and not for sale in your territory.
Based on 14 publication(s) in Google Scholar
Other Forms of Captopril:
- Captopril hydrochloride Obtenir un devis
- Captopril-d3 Obtenir un devis
Description |
Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM[1][2][3]. |
IC50 & Target |
ACE[1]. |
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In Vitro |
Captopril (SQ 14225) has been shown to have similar morbidity and mortality benefits to those of diuretics and beta-blockers in hypertensive patients. Captopril has been shown to delay the progression of diabetic nephropathy, and enalapril and lisinopril prevent the development of nephropathy in normoalbuminuric patients with diabetes[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Essai clinique |
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Masse moléculaire |
217.29 |
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Formule |
C9H15NO3S |
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CAS No. |
62571-86-2 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(O)[C@H]1N(C([C@H](C)CS)=O)CCC1 |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
DMSO : ≥ 50 mg/mL (230.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : ≥ 50 mg/mL (230.11 mM) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO / H2O | 1 mM | 4.6021 mL | 23.0107 mL | 46.0214 mL | 115.0536 mL |
5 mM | 0.9204 mL | 4.6021 mL | 9.2043 mL | 23.0107 mL | |
10 mM | 0.4602 mL | 2.3011 mL | 4.6021 mL | 11.5054 mL | |
15 mM | 0.3068 mL | 1.5340 mL | 3.0681 mL | 7.6702 mL | |
20 mM | 0.2301 mL | 1.1505 mL | 2.3011 mL | 5.7527 mL | |
25 mM | 0.1841 mL | 0.9204 mL | 1.8409 mL | 4.6021 mL | |
30 mM | 0.1534 mL | 0.7670 mL | 1.5340 mL | 3.8351 mL | |
40 mM | 0.1151 mL | 0.5753 mL | 1.1505 mL | 2.8763 mL | |
50 mM | 0.0920 mL | 0.4602 mL | 0.9204 mL | 2.3011 mL | |
60 mM | 0.0767 mL | 0.3835 mL | 0.7670 mL | 1.9176 mL | |
80 mM | 0.0575 mL | 0.2876 mL | 0.5753 mL | 1.4382 mL | |
100 mM | 0.0460 mL | 0.2301 mL | 0.4602 mL | 1.1505 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.