Product Description

ERBB2/CEN 17 CISH Probe Kit is designed for the qualitative detection of amplifications involving the human ERBB2 gene as well as the detection of chromosome 17 alpha satellites in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).

Form

Liquid

Recommend Usage

The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (18-25°C) and mix briefly before use.

Supplied Product

Reagent Provided:

This Probe is composed of:
1. Digoxigenin-labeled polynucleotides, which target sequences mapping in 17q12 (chr17:37,725,661-37,973,541) harboring the ERBB2 gene region.
2.Dinitrophenyl-labeled polynucleotides, which target sequences mapping in 17p11.1-q11.1 specific for the alpha satellite centromeric region D17Z1 of chromosome 17.
3. Formamide based hybridization buffer.

Probe Position

Regulatory Status

For research use only (RUO)

Storage Instruction

Store at 2-8°C in an upright position. Return to storage conditions immediately after use.

Note

Interpretation of the results must be made within the context of the patient´s clinical history with respect to further clinical and pathologic data of the patient by a qualified pathologist.

Interpretation of Result